Enclomiphene

Enclomiphene 100x10mg

Manufacturer: Black Labs

Package: 100 tablets

Common Names: Enclomiphene, Enclomiphene Citrate, Enclomiphene 10mg

Info: Enclomiphene is the trans-isomer of clomiphene citrate and belongs to the class of selective estrogen receptor modulators (SERMs). It has been investigated for its effects on the hypothalamic-pituitary-gonadal axis, particularly in men with secondary hypogonadism. By interacting with estrogen receptors in the hypothalamus and pituitary, enclomiphene may reduce estrogen-mediated negative feedback and influence the endogenous production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These gonadotropins play important roles in regulating testicular testosterone production and spermatogenesis.

Effects

Enclomiphene primarily acts through estrogen receptor modulation at the hypothalamic-pituitary level. By reducing estrogen-mediated negative feedback, it may increase the release of LH and FSH, which can subsequently support endogenous testosterone production in the testes.

Clinical research has investigated enclomiphene in men with secondary hypogonadism, including its potential to increase serum testosterone while preserving gonadotropin activity and aspects of reproductive function. The observed response can vary depending on the underlying cause of hormonal imbalance and individual physiological factors.

Side Effects

Potential adverse effects associated with enclomiphene may include headache, nausea, mood changes, visual disturbances, and other hormonal or estrogen-related effects. Changes in hormone levels may also be accompanied by alterations in libido or other symptoms. The complete long-term safety profile of enclomiphene has not been fully established, and continued clinical monitoring may be required during prolonged use.

Dosage Range and Duration of Use

In clinical studies and therapeutic practice for secondary hypogonadism, enclomiphene citrate is typically administered orally at daily doses ranging from 12.5 mg to 25 mg, often started at 12.5 mg once daily and adjusted based on response. Alternate-day dosing schedules (12.5 mg every other day) are also utilized to maintain target testosterone levels. Treatment duration generally spans from 3 to 6 months, though long-term therapy requires ongoing professional medical assessment and periodic laboratory monitoring.    

Combination with Other Drugs

Enclomiphene may interact with medications that affect hormonal signaling or hepatic drug metabolism. Particular consideration may be required when combining it with testosterone, other SERMs, hormonal therapies, or medications that influence the hypothalamic-pituitary-gonadal axis. Before using enclomiphene, a healthcare professional should be informed about all prescription medicines, over-the-counter products, and supplements being taken to help identify potential interactions.